A plague event would be awesome, sure!
I usually prefer to have characters see everyone sick around them and be completely helpless. One of my characters wouldn't be affected due to not being technically living, and a few of my sturdier characters would likely not be, but both of my living characters from Easton (Jannisia, Amilin) should be GREATLY affected, and I'm willing to let Teefa be a carrier, getting only a little sick.
Kini shouldn't be able to catch it at all, seeing as she's a completely different class of creature from most of the islanders, and neither should Shamaelistor, who isn't a complete being. Not sure if Ambros would be affected, but I'll play it as I see it, because shi does get sick and eventually all normal stuff will mutate into being able to affect Mana Corrupted.
Nightpelt might be another carrier, or he might full out catch the plague, but if Bedelia catches it she will have it worse than the ones from Easton.
So that's four affected out of my nine, three unaffected, and two carriers. If this event happens.